de novo

[ dee noh-voh, dey, dih; Latin de noh-woh ]

adverb

1. anew; afresh; again; from the beginning:

   We reviewed the court’s decision de novo during the rehearing.

2. independently of external forces; from within; spontaneously:

   Mutations associated with autism often occur de novo rather than through inheritance.

adjective

1. occurring or arising spontaneously or independently of external forces; spontaneous: de novo synthesis of steroids from cholesterol.

   de novo mutations;

   de novo synthesis of steroids from cholesterol.

2. made from scratch rather than developed from or based on something preexisting, and hence new, novel, or of a new type: de novo banks.

   de novo protein design;

   de novo banks.

3. De No·vo, noting or related to a type of FDA classification allowing novel medical devices with no precedent on the market to be sold: De Novo classification.

   a De Novo request;

   De Novo classification.

de novo

/ diː ˈnəʊvəʊ /

adverb

1. from the beginning; anew

Word History and Origins

Origin of de novo¹

First recorded in 1620–30; from Latin dē novō “anew, afresh, again”

Example Sentences

Researchers are, therefore, trying to recreate them or to design so-called de novo proteins that do not occur in nature.

From Science Daily

"These de novo or reference-guided assemblers are pretty well-established tools that entail a whole operational pipeline with repeat detection or structural variants' identification being just some of their functionalities," Segarra said.

From Science Daily

However, de novo domesticated crops are likely to closely resemble their wild counterparts, which would make weeding challenging.

From Science Daily

Today, scientists use advanced technology to design new synthetic drug compounds with the right properties and characteristics, also known as "de novo drug design."

From Science Daily

The drug works by impairing one arm of purine production, the "de novo" pathway.

From Science Daily

Related Words

• afresh
• once again
• once more
• recently